赖氨葡锌颗粒联合鞣酸蛋白酵母散治疗小儿急性腹泻的疗效观察

目的探讨赖氨葡锌颗粒联合鞣酸蛋白酵母散治疗小儿急性腹泻的临床疗效。方法选取天津市西青医院2015年8月—2016年8月收治的急性腹泻病患儿111例,随机分成对照组(55例)和治疗组(56例)。对照组患儿口服鞣酸蛋白酵母散,小于1岁患儿1包/次,1~3岁患儿2包/次,大于3岁患儿3包/次,均为3次/d;治疗组在对照组的基础上口服赖氨葡锌颗粒,小于1岁患儿半包/次,1~3岁患儿1包/次,大于3岁患儿2包/次,均为1次/d。所有患儿均规律治疗5 d。评价两组患者临床疗效,同时比较治疗前后两组患者主要症状评分、体温、大便和呕吐症状恢复时间改善情况。结果治疗后,对照组临床总有效率为81.82%,显著低于治疗组的96.43%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿便次增多、大便稀软、呕吐评分均显著降低(P0.05);且治疗组便次增多和呕吐评分均显著低于对照组患儿(P0.05)。治疗后,治疗组患儿体温、大便、呕吐症状恢复时间均显著短于对照组患儿,两组比较差异具有统计学意义(P0.05)。结论赖氨葡锌颗粒联合鞣酸蛋白酵母散治疗小儿急性腹泻临床疗效较好,安全性高,具有一定的临床推广应用价值。

Clinical observation of Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with Albumin Tannate and Barm Powder in treatment of acute diarrhea in children

Objective To explore the clinical efficacy of Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with Albumin Tannate and Barm Powder in treatment of acute diarrhea in children. Methods Children (111 cases) with acute diarrhea in Tianjin Xiqing Hospital from August 2015 to August 2016 were randomly divided into control (55 cases) and treatment (56 cases) groups. Children in the control group were po administered with Albumin Tannate and Barm Powder, 1 bag/time for children under 1 year old, 2 bags/time for children 1-3 years old, 3 bags/time for children over 3 years old, three times daily. Children in the treatment group were po administered with Compound Lysine Hydrochloride and Zinc Gluconate Granules on the basis of the control group, 0.5 bag/time for children under 1 year old, 1 bag/time for children 1-3 years old, 2 bags/time for children over 3 years old, once daily. Children in two groups were treated for 5 d. After treatment, clinical efficacy was evaluated, and the improvement of main symptom score, body temperature, bowel, and recovery time of vomiting symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.82%, which was significantly lower than 96.43% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the diarrhea clinical symptom scores in two groups were significantly decreased (P<0.05). And the increased stool and vomiting scores in the treatment group were obviously lower than those in the control group (P<0.05). After treatment, the recovery time of body temperature, stool, and vomiting symptoms in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). Conclusion Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with Albumin Tannate and Barm Powder has good effect in treatment of acute diarrhea in children with high security, which has a certain clinical application value.