肾康注射液联合包醛氧淀粉治疗慢性肾功能衰竭的临床研究

目的探讨肾康注射液联合包醛氧淀粉胶囊治疗慢性肾功能衰竭的临床疗效。方法选取2014年4月—2016年4月在海口市人民医院接受治疗的慢性肾功能衰竭患者80例,采用随机数字表分为对照组和治疗组,每组各40例。对照组口服包醛氧淀粉胶囊,8粒/次,3次/d。治疗组在对照组基础上静脉滴注肾康注射液,100 mL加入到10%葡萄糖注射液300 mL中,1次/d。两组患者均治疗4周。观察两组的临床疗效,比较两组的24 h尿蛋白(24 h Pro)、尿素氮(BUN)、血肌酐(Scr)、β_2-微球蛋白(β_2-MG)、转化生长因子-β_1(TGF-β_1)、肿瘤坏死因子-α(TNF-α)、可溶性细胞黏附因子-1(sICAM-1)和白细胞介素-1β(IL-1β)的水平。结果治疗后,对照组和治疗组的总有效率分别为80.00%、97.50%,两组比较差异有统计学意义(P0.05)。治疗后,两组24 h Pro、BUN、Scr和β_2-MG水平均明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血清TGF-β_1、TNF-α、sICAM-1、IL-1β水平明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论肾康注射液联合包醛氧淀粉胶囊治疗慢性肾功能衰竭具有较好的临床疗效,可改善患者肾功能,降低机体炎症反应,具有一定的临床推广应用价值。

Clinical study of Shenkang Injection combined with coated aldehyde oxystarch in treatment of chronic renal failure

Objective To investigate the clinical efficacy of Shenkang Injection combined with Coated Aldehyde Oxystarch Capsules in treatment of chronic renal failure. Methods Patients (80 cases) with chronic renal failure in Haikou People's Hospital from April 2014 to April 2016 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Coated Aldehyde Oxystarch Capsules, 8 grains/time, three times daily. Patients in the treatment group were iv administered with Shenkang Injection on the basis of the control group, 100 mL added into 10% glucose solution 300 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the levels of 24 h Pro, BUN, Scr, β2-MG, TGF-β1, TNF-α, sICAM-1, and IL-1β in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 97.50%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of 24 h Pro, BUN, Scr, and β2-MG in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TGF-β1, TNF-α, sICAM-1, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shenkang Injection combined with Coated Aldehyde Oxystarch Capsules has clinical curative effect in treatment of chronic renal failure, can improve renal function, and decrease inflammatory reaction, which has a certain clinical application value.