眩晕宁颗粒联合天麻素注射液治疗眩晕的疗效观察

目的观察眩复宁颗粒联合天麻素注射液治疗眩晕的临床疗效。方法选取2014年1月—2016年12月在资阳市第一人民医院接受治疗的眩晕患者68例,随机分为对照组和治疗组,每组各34例。对照组静脉滴注天麻素注射液,0.6 g加入生理盐水250 mL。治疗组在对照组的基础上口服眩晕宁颗粒,8 g/次,3次/d。两组均连续治疗7 d。评价两组患者临床疗效,同时比较治疗前后两组患者症状改善不同时间人数、血液流变学和血脂差异。结果治疗后,对照组临床总有效率为79.41%,显著低于治疗组的91.02%,两组比较差异具有统计学意义(P0.05)。治疗1、3、5 d后,治疗组症状改善人数明显多于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者红细胞聚集指数、全血黏度和红细胞压积等血液流变学指标以及三酰甘油(TG)、总胆固醇(TC)和低密度脂蛋白(LDL-C)等血脂水平均显著降低,同组比较差异具有统计学意义(P0.05);且治疗组患者血液流变学和血脂降低程度比对照组更显著,两组比较差异具有统计学意义(P0.05)。结论眩晕宁颗粒联合天麻素注射液治疗眩晕疗效较好,安全性高,具有一定的临床推广应用价值。

Clinical observation of Xuanyunning Granules combined with Gastrodine Injection in treatment of vertigo

Objective To observe the clinical curative effect of Xuanyunning Granules combined with Gastrodine Injection in treatment of vertigo. Methods Patients (68 cases) with vertigo in Ziyang First People''s Hospital from January 2014 to December 2016 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were iv administered with Gastrodin Injection, 0.6 g added into normal saline 250 mL. Patients in the treatment group were po administered with Xuanyunning Granules on the basis of the control group, 8 g/time, three times daily. After treatment, clinical efficacy was evaluated, and the difference of the patients of different symptoms improvement time, and hemorheology and blood lipids in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 79.41%, which was significantly lower than 91.02% in the treatment group, and there were differences between two groups (P<0.05). After treatment for 1, 3, and 5 d, the patients of different symptoms improvement time in the treatment group were significantly more than patients in the control group (P<0.05). After treatment, the hemorheological indexes of erythrocyte aggregation index, whole blood viscosity and hematocrit, and blood lipids levels of TG, TC, and LDL-C in two groups were significantly decreased, the difference was statistically significant in the same group (P<0.05). And the hemorheology and blood lipids in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xuanyunning Granules combined with Gastrodine Injection had good effect in treatment of vertigo, which has a certain clinical application value.