电感耦合等离子体发射光谱法测定右旋糖酐铁中重金属元素时的基体效应和内标校正方法研究

目的 建立用电感耦合等离子体发射光谱法（ICP-OES）测定右旋糖酐铁中铅、镉、砷、汞、钴、钒、硒、钼8种重金属元素含量的分析方法。方法 通过检测波长考察，仪器参数优化，验证基体效应干扰，考察内标物校正干扰，测定8种重金属元素的含量。结果 内标法校正基体效应干扰，待测元素回收率由83%~90%提高为94%~100%，方法准确度良好，加标回收率在94.3%~101.5%，方法精密度良好（RSD<3.5%，n=6）。各待测元素线性关系良好，相关系数均大于0.999，检出限为0.22~8.54 ng/mL，定量限为0.68~25.73 ng/mL。结论 方法准确度高、灵敏度高、迅速可靠，可用于右旋糖酐铁中8种重金属元素含量的测定。

Correction of matrix effect in determination of heavy metal elements in iron dextran by icp-oes internal standard method

Objective To establish a method for the determination of 8 heavy metal elements of Pb, Cd, As, Hg, Co, V, Se, Mo in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES). Method Through selection of detection wavelengths, optimization of instrument parameters, verification of matrix effect interference and investigation of internal standard for correction of matrix effect interference, the 8 heavy metal elements were analyzed by ICP-OES. Results The recovery rate of the detected elements were increased from 83%-90% to 94%-100%, after correction of matrix effect interference by internal standard method. The accuracy of the method were good. The spiked recoveries of the detected elements were from 94.3% to 101.5%. The precision of the method were good (RSD<3.5%, n=6). The linearities of the detected elements were good, and the correlation coefficients were all greater than 0.999. The detection limits were from 0.22 to 8.54 ng/mL. The quantization limits were from 0.68 to 25.73 ng/mL. Conclusion The established method was accurate, sensitivity, rapid and reliable, which can be applied to the determination of contents of 8 heavy metal elements in iron dextran.