盐酸氨溴索联合止咳平喘糖浆治疗小儿咳嗽的临床研究

目的 研究盐酸氨溴索联合止咳平喘糖浆治疗小儿咳嗽的临床效果。方法 选择2012年1月-2015年12月在成都市龙泉驿区妇幼保健院进行诊治的咳嗽患儿200例，随机分为两组。观察组采用盐酸氨溴索联合止咳平喘糖浆治疗，对照组采用盐酸氨溴索治疗。两组均治疗2周。观察患儿治疗完成后的临床症状和临床表现，记录咳嗽好转时间及咳嗽消失时间，并进行治疗效果的判定，检测两组患儿的肺功能指标：呼气流量峰值、用力肺活量、一秒钟用力呼气量、50%肺活量最大呼气流速与25%肺活量最大呼气流速，并在治疗结束后，对所有患儿通过电话或门诊随访6个月，观察两组的复发率，并记录转变为哮喘的患儿例数。结果 观察组的咳嗽好转时间及咳嗽消失时间均明显短于对照组，差异有统计学意义（P<0.05）。观察组的总有效率为93.00%，明显高于对照组的74.00%，差异有统计学意义（P<0.05）。经过治疗后，两组的呼气流量峰值、用力肺活量、一秒钟用力呼气量、50%肺活量最大呼气流速与25%肺活量最大呼气流速均明显升高，统计治疗前后比较差异有统计学意义（P<0.05）；且观察组的升高幅度明显优于对照组，差异有统计学意义（P<0.05）。经过6个月的随访发现，对照组有22例患儿复发，复发率为22.00%；观察组有6例复发，复发率为6.00%，观察组患儿的复发率明显低于对照组，差异有统计学意义（P<0.05）；对照组有14例患儿转变为哮喘，转变率为14.00%；观察组有2例患儿转变为哮喘，转变率为2.00%，观察组患儿的转变率明显低于对照组，差异有统计学意义（P<0.05）。结论 盐酸氨溴索联合止咳平喘糖浆对小儿咳嗽具有较好的疗效，可以有效改善患儿的肺功能，降低复发率和哮喘转变率，具有较高的临床应用价值。

Clinical study on effect of HCL combined with Bromine Hydrochloride on infantile cough

Objective To investigate the clinical effect of ambroxol hydrochloride combined with cough syrupintegrated traditional Chinese and Western Medicine on infantile cough. Methods Selected 200 cases of patients with cough who were treated in our hospital from January 2012 to December 2015, divided into two groups randomly, 100 cases in observation group, 100 cases in control group. The observation group was treated with ambroxol hydrochloride combined with cough syrup, the control group were treated with ambroxol hydrochloride. To observe the clinical symptoms and clinical manifestations of the patients after treatment, recorded the time of cough and the disappearance of cough, and to determine the effect of treatment. The lung function indexes of the two groups were detected:peak expiratory flow, forced vital capacity, forced expiratory volume in one second, maximal expiratory flow rate of 50% vital capacity and maximal expiratory flow rate of 25% vital capacity. All the patients were followed up for 6 months by telephone or clinic, the recurrence rate of the two groups was observed, and the number of children with asthma were recorded. Results The time of cough and the disappearance time of cough in observation group were significantly shorter than that of the control group (P<0.05); the total effective rate of observation group was 93.00% (93/100), significantly higher than that of the control group 74.00% (74/100) (P<0.05). After treatment, expiratory flow peak, forced vital capacity, one second forced expiratory volume, vital capacity 50% of maximum expiratory flow and 25% of vital capacity maximal expiratory flow of two groups were significantly increased (P<0.05) and the observation group increased more significantly than the control group (P<0.05). After 6 months of follow-up, the control group had 22 cases of recurrence, the recurrence rate was 22.00%; the observation group had 6 cases of recurrence, the recurrence rate was 6.00%, the recurrence rate of the observation group was significantly lower than that of the control group (P<0.05); the control group had 14 cases of children with asthma, the change rate was 14%; the observation group had 2 cases of children with asthma, the change rate was 2%, the change rate of the observation group was significantly lower than that of the control group (P<0.05). Conclusion Ambroxol hydrochloride combined with cough syrup has better curative effect on infantile cough, can effectively improve children''s lung function, reduce the rate of recurrence and change of asthma, which has high clinical application value.