双歧杆菌三联活菌胶囊联合生长抑素治疗急性胰腺炎的临床研究

目的探讨双歧杆菌三联活菌胶囊联合生长抑素治疗急性胰腺炎的临床疗效。方法选取2012年1月—2016年6月在亳州市人民医院治疗的急性胰腺炎患者136例,随机分为对照组和治疗组,每组各68例。对照组静脉注射注射用生长抑素,首次使用微量泵静脉推注100μg,然后以50μg/h匀速泵入。治疗组在对照组的基础上口服双歧杆菌三联活菌胶囊,4粒/次,1次/12 h。两组患者连续治疗14 d。评价两组患者临床疗效,同时比较治疗前后两组患者白细胞(WBC)、C反应蛋白(CRP)、淀粉酶(AMY)和乳酸脱氢酶(LDH)等生化指标以及胃肠道功能评分。结果治疗后,对照组和治疗组总有效率分别为82.35%和92.65%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者WBC、CRP、AMY和LDH生化指标以及胃肠道功能评分均显著降低,同组比较差异具有统计学意义(P0.05);且治疗组上述观察指标显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论双歧杆菌三联活菌胶囊联合生长抑素治疗急性胰腺炎疗效显著,具有一定的临床推广应用价值。

Clinical study on Bifidobacterium Triple Live Capsules combined with somatostatin in treatment of acute pancreatitis

Objective To explore the clinical efficacy of Bifidobacterium Triple Live Capsules combined with somatostatin in treatment of acute pancreatitis. Methods Patients (136 cases) with acute pancreatitis in Bozhou People's Hospital from January 2012 to June 2016 were randomly divided into control and treatment groups, and each group had 68 cases. Patients in the control group were iv administered with Somatostatin for injection, intravenous infusion 100 μg with a micro pump for the first time, then uniform pumping with a 50 μg/h speed. Patients in the treatment group were po administered with Bifidobacterium Triple Live Capsules on the basis of the control group, 4 grains/time, once every 12 h. Patients in two groups were treated for 14 d. After treatment, clinical efficacy was evaluated, and the biochemical indexes of WBC, CRP, AMY, and LDH, and gastrointestinal function scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.35%and 92.65%, respectively, and there were differences between two groups (P < 0.05). After treatment, the biochemical indexes of WBC, CRP, AMY, and LDH, and gastrointestinal function scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these observation indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Bifidobacterium Triple Live Capsules combined with somatostatin has significant effect in treatment of acute pancreatitis, which has a certain clinical application value.