| 视网膜新生血管抑制因子的研究进展 |
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| 引用本文： | 罗琰君,徐国兴.视网膜新生血管抑制因子的研究进展[J].国际眼科杂志,2017,17(9):1663-1666. |
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| 作者姓名： | 罗琰君 徐国兴 |
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| 作者单位： | 福建医科大学附属第一医院 福建省眼科研究所, 中国福建省福州市,350005 |
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| 基金项目： | 国家自然科学基金资助项目(No.81271026); 福建省科技创新领军人才基金资助项目(No.2016B011) |
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| 摘 要： | 血管的正常生长是血管组织中促生长因子和抑制因子相互协调达到动态平衡的结果,但是当这种平衡被打破后,就会诱发新生血管的生长.内源性的新生血管抑制因子,是一组机体自身产生的抑制血管生成的负反馈分子,其产生血管抑制的作用主要是通过影响促新生因子与其受体或其下游促增生信号结合,或者自身促进内皮凋亡而实现的.血管新生抑制因子的研究对于防治眼底视网膜新生血管生长具有潜在的临床意义.本文就视网膜新生血管抑制因子的最新研究进展进行系统综述.
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| 关 键 词： | 视网膜新生血管 内皮抑素 色素上皮衍生因子 血管抑素 可溶性VEGF受体阻断剂 基质金属蛋白酶抑制因子 VEGF siRNA |
| 收稿时间： | 2017/2/12 0:00:00 |
| 修稿时间： | 2017/7/28 0:00:00 |
Research advance of retinal neovascularization inhibitory factor |
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| Yan-Jun Luo and Guo-Xing Xu.Research advance of retinal neovascularization inhibitory factor[J].International Journal of Ophthalmology,2017,17(9):1663-1666. |
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| Authors: | Yan-Jun Luo and Guo-Xing Xu |
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| Institution: | Fujian Institute of Ophthalmology; the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China and Fujian Institute of Ophthalmology; the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China |
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| Abstract: | The normal growth of blood vessels is the result of dynamic balance of angiogenic factor and inhibitory factor in vascular tissue. However, when the balance is broken, the growth of new blood vessels will be induced. Endogenous angiogenesis inhibitory factor, is a group of negative feedback molecules produced by the body itself that inhibit angiogenesis. Its function of inhibiting angiogenesis is mainly realized by promoting the binding of angiogenic factor to its receptor, or its downstream angiogenesis signal, or promoting vascular endothelial apoptosis. The study of angiogenesis inhibitory factor has potential clinical significance for the prevention and treatment of retinal neovascularization. Recent studies on retinal neovascularization inhibitory factor are reviewed in this paper. |
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| Keywords: | retinal neovascularization endostatin pigmet epithelium-derived factor angiostain soluble VEGF receptor inhibitor tissue inhibitors of matrix metalloprotinase VEGF siRNA |
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