p53蛋白在非小细胞肺癌中表达及与其临床特征、同步放化疗疗效的关系分析 |
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引用本文: | 刘东芳,王晓红,刘春秋,赵洪焕,张晓斌,杨俊泉,张成侠,王建功,汪宏斌,赵凯. p53蛋白在非小细胞肺癌中表达及与其临床特征、同步放化疗疗效的关系分析[J]. 实用癌症杂志, 2016, 0(1): 26-28. DOI: 10.3969/j.issn.1001-5930.2016.01.008 |
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作者姓名: | 刘东芳 王晓红 刘春秋 赵洪焕 张晓斌 杨俊泉 张成侠 王建功 汪宏斌 赵凯 |
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作者单位: | 063000,河北省唐山市人民医院 |
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摘 要: | 目的:检测p53蛋白在非小细胞肺癌患者中的表达水平,并探讨其表达与临床特征的相关性及同步放化疗疗效的关系。方法采用免疫组化方法,检测100例非小细胞肺癌组织中p53表达水平,结合显微图像分析仪测定p53免疫组化强度,以阳性单位为定量分析单位。分析p53表达水平与患者临床病理特征及同步放化疗疗效的关系。结果 p53蛋白在非小细胞肺癌中阳性表达率为48%;p53表达与淋巴结转移、远端转移和TNM分期均无显著相关性;非小细胞肺癌p53蛋白表达者放化疗效果显著低于p53蛋白表达阴性患者,且p53蛋白表达与患者生存期呈负相关。结论 p53表达与否影响非小细胞肺癌患者化疗效果,与生存期直接相关,临床治疗时可考虑将其作为治疗靶点。
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关 键 词: | 非小细胞肺癌 p53 同步化疗 |
The Correlations between p53 Expression and Clinical Characteristics and Chemo-radiotherapy Efficacy in Non-small Cell Lung Cancer |
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Abstract: | Objective To investigate p53 expression in non-small cell lung cancer,and its relationships with clinical characteristics and chemoradiotherapy efficacy.Methods Immunohistochemistry was used to detect the expression of p53 in 100 cases of non-small cell lung cancer tissues,and the expression strength was detected using micro image analyzer.The relationships between p53 expression and clinical characteristics and chemo-radiotherapy efficacy were analyzed.Results The positive rate of p53 in non-small cell lung cancer was 48%;there were no correlations among p53 expression and lymph node metastasis,distant metastasis or TNM stage;NSCLC patients with p53 expression had worse chemo-radiotherapy effect than those without p53 expres-sion,and p53 expression was negatively associated with patients'survival time.Conclusion The status of p53 expression have effect on synchronous chemotherapy in patients with non-small cell lung cancer,and is directly related with the survival time.p53 may be represented as a promising target for non-small cell lung cancer. |
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Keywords: | Non-small cell lung cancer p53 Synchronous chemotherapy |
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