NSCLC 恶性胸腔积液患者存活率的影响因素分析

目的：探讨非小细胞肺癌恶性胸腔积液患者存活率的影响因素。方法回顾性分析199例非小细胞肺癌恶性胸腔积液患者的临床资料，将患者年龄、性别、吸烟史、转移位点、病理形态、乳酸脱氢酶、血小板、血清C反应蛋白、顺铂胸腔内灌注这9个因素作为研究对象，采用COX多因素回归分析NSCLC恶性胸腔积液存活率的独立影响因子。结果单因素分析显示病理形态、乳酸脱氢酶、血清C反应蛋白、顺铂胸腔内灌注是患者预后影响因素，COX多因素回归分析显示血清C反应蛋白和顺铂胸腔内灌注为预后独立的影响因子。结论血清反应蛋白和顺铂胸腔内灌注为预后独立的影响因子。

Prognostic Factor Affecting Survival in NSCLC Patients with Malignant Pleural Effusions

Objective To investigate the factors affecting survival in non-small cell lung cancer( NSCLC) patients with malignant pleural effusion.Methods The clinical data of 199 cases of NSCLC patients with malignant pleural effusion were retro-spectively analyzed.Age,gender,smoking status,metastatic sites,histopathological type,LDH,platelets,CRP,cisplatin intrathorac-ic perfusion were analyzed,and COX regression analysis was used to analyze the influence factors of NSCLC patients with malig-nant pleural effusions.Results Single factor analysis showed that pathological morphology,lactate dehydrogenase,serum CRP, and cisplatin in patients with pleural perfusion were prognostic factors,and COX regression analysis showed that CRP,cisplatin in-trathoracic perfusion were independent prognostic factors.Conclusion CRP and cisplatin intrathoracic perfusion are independent prognostic factors.