血清中 MMP-9、TIMP-1表达水平与肺癌病理特征的关系分析

目的：检测肺癌患者血清MMP-9、TIMP-1水平变化，探讨其与肺癌患者病理特征的关系。方法选取80例肺癌患者为研究对象，另选取30例正常健康者为对照组，ELISA法测定肺癌患者及正常者血清中MMP-9、TIMP-1水平，比较两组之间差异。结果肺癌患者血清MMP-9、TIMP-1水平均显著高于正常者（ P＜0．01），肺癌患者血清中MMP-9、TIMP-1表达水平与肺癌病理类型、病理分化程度无关（P＞0．05），与肿瘤体积大小、TNM分期、淋巴结转移、远处转移相关，肿瘤≥3 cm患者血清中MMP-9、TIMP-1水平明显高于肿瘤≤3 cm的患者；Ⅲ＋Ⅳ期患者血清中MMP-9、TIMP-1水平明显高于Ⅰ＋Ⅱ期患者；淋巴结转移患者血清中MMP-9、TIMP-1水平明显高于无淋巴结转移患者；远处转移患者血清中MMP-9、TIMP-1水平明显高于无远处转移患者；肺癌患者MMP-9表达与TIMP-1表达呈正相关（γ＝0．634，P＜0．05）。结论 MMP-9、TIMP-1在肺癌患者中表达与TNM分期、淋巴结转移、远处转移相关，在肺癌侵袭转移中有重要作用，可监测病情发展。

Analysis of Relationship between MMP-9 and TIMP-1 Expression in Serum and Pathological Features of Patients with Lung Cancer

Objective To observe the change of MMP-9 and TIMP-1 expression in serum of patients with lung cancer, and to explore its relationship with the pathological features.Methods 80 cases of lung cancer patients were selected as the stud-y group,and 30 cases of normal healthy patients were selected as the control group,MMP-9 and TIMP--1 levels in serum of lung cancer patients were detected by ELISA assay,the difference between the 2 groups were compared.Results MMP-9,TIMP-1 lev-els of patients with lung cancer were significantly higher than those of normal patients(P<0.01),MMP-9 and TIMP-1 expression had no relation with pathological type,pathological differentiation degree (P>0.05),but was related to tumor size,TNM stage, lymph node metastasis,distant metastasis.MMP-9 and TIMP-1 levels of patients with tumor≥3 cm serum were significantly high-er than patients with tumor ≤3 cm;MMP-9 and TIMP-1 levels of stage ⅢandⅣpatients were significantly higher than stage ⅠandⅡpatients;MMP-9 and TIMP-1 levels in patients with lymph node metastasis were significantly higher than those without lymph node metastasis;MMP-9 and TIMP-1 levels in patients with distant metastases were significantly higher than those without distant metastasis.Conclusion MMP-9 and TIMP-1 expression in lung cancer patients is related to TNM stage,lymph node me-tastasis and distant metastasis,it plays an important role in cancer invasion and metastasis,and it can monitor disease progression.