|
|||||
|
|
Role of glucose-regulated Protein 78 in embryonic development and neurological disorders |
|
| Authors: | Weng Wen-Chin Lee Wang-Tso Hsu Wen-Ming Chang Bei-En Lee Hsinyu |
| Institution: | a Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan b Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan c Graduate Institute of Oral Biology, College of Medicine, National Taiwan University, Taipei, Taiwan d Deparments of Life Science, National Taiwan University, Taipei, Taiwan e Institute of Zoology, National Taiwan University, Taipei, Taiwan |
| Abstract: | Glucose-regulated protein 78 (GRP78) is an important chaperone protein that is predominantly expressed in the endoplasmic reticulum. The multifunctional roles of GRP78 in protein folding, endoplasmic reticulum calcium binding, cytoprotection, and anti-apoptosis, as well as its function as a receptor on the cell surface, disclose its major involvement in physiological and numerous pathological conditions. Recent advances in mouse models targeting GRP78 allele have revealed the essential roles of GRP78 in development and neurological disorders, as well as accurate neural migration and neuroprotection. This review of correlation between GRP78 and embryogenesis and neurological disorders provides further directions for investigation, as well as potential therapeutics for clinical use. |
| Keywords: | embryonic development endoplasmic reticulum stress glucose-regulated protein 78 neurological disorders unfolded protein response |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |