A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects |
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| Authors: | G. J. Veldhuis A. H. D. van der Leest J. T. M. de Wolf E. G. E. de Vries E. Vellenga |
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| Affiliation: | (1) Department of Internal Medicine, Division of Medical Onocology, University Hospital Groningen, P.O.Box 30.001, NL-9700 RB Groningen, The Netherlands, NL;(2) Department of Radiotherapy, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The Netherlands, NL;(3) Department of Internal Medicine, Division of Hematology, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The Netherlands, NL |
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| Abstract: | A patient is presented who had Castleman's disease with constitutional symptoms, a palpable supraclavicular/axillar mass, and a microcytic anemia, among other laboratory abnormalities, including elevated levels of interleukin-6. Treatment consisted of irradiation of the involved area, with subsequent disappearance of all symptoms and normalization of the laboratory abnormalities. Iron kinetic studies demonstrated a hypoproliferative erythropoiesis, which normalized after radiotherapy. Hypoproliferative erythopoiesis could not be ascribed to serum inhibitors, since normal burst-forming units were observed in the absence or presence of autologous serum. The role of interleukin-6 in relation to Castleman's disease is highlighted. Received: 18 December 1995 / Accepted 27 March 1996 |
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| Keywords: | Giant lymph-node Hyperplasia Castleman's disease Radiotherapy Interleukin-6 Anemia |
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