适形放射治疗联合热疗治疗晚期胰腺癌的疗效及临床受益反应观察

为了评价适形放疗联合热疗治疗晚期胰腺癌的疗效及临床受益反应,对34例胰腺癌患者给予适形放疗,2Gy/次,5次/周,总剂量50-70 Gy;热疗2次/周,每次60-90 min,共计6次。结果82.4%患者胸背部疼痛明显缓解,临床受益反应有效率91.2%;放疗后2个月复查CT,肿瘤缩小〉25%者76.5%;1、2年生存率分别为38.2%和20.6%。初步研究结果提示,适形放射治疗联合热疗治疗晚期胰腺癌,疗效较好,并发症少,可显著提高患者生活质量,是不能手术患者较好的治疗方式。

Conformal radiotherapy combined with hyperthermia for advanced, unresectable pancreatic cancer

The objective of this study was to evaluate the therapeutic effect of conformal radiotherapy combined with concurrent hyperthermia on advanced,unresectable pancreatic cancer.Thirty-four patients with advanced pancreatic carcinoma received conformal radiotherapy with 2 Gy/fraction, 5 fraction/week,a total dose 50-70 Gy,and at the same time,hyperthermia was pertormed,twice a week for 6 fraction,60-90 minutes/fraction.Results: 82.4% of the patients who suffered from pain got relief,and the clinical benefit reponse was 91.2%.The over all response rate(CR+PR) were 76.5%,and 1-year and 2year survival rates were 38.2% and 20.6%.Conclusion: The conformal radiotherapy combined with concurrent hyperthermia is an effective approach to improve life quality and prolong survival time for unresectable pancreatic carcinoma.