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INTERACTION OF RETINOL AND RETINOIC ACID WITH THE NUCLEUS
Abstract:Intracellular binding proteins for retinol and retinoic acid have been described. A nuclear retinoic acid receptor also has been detected. Pure cellular retinol-binding protein, containing bound labeled retinol was found to bind to isolated, purified rat liver nuclei. The binding was highly specific and saturable, showing about 3 times 105 specific binding sites per nucleus.
Keywords:retinoids    retinol    retinoic acid    vitamin A    steroid hormones    nucleus    cytosol    cellular retinol-binding protein    cellular retinoic acid-binding protein
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