Adenomyoepithelioma of the breast diagnosed by a mammotome biopsy: Report of a case |
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Authors: | Toshiro Yahara Rin Yamaguchi Goro Yokoyama Miki Yamaguchi Shino Nakagawa Uhi Toh Kazuo Shirouzu Masayoshi Kage Teruhiko Fujii |
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Institution: | (1) Departments of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan;(2) Departments of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan;(3) Department of Surgery, Kyusyu Medical Center, National Hospital Organization, Fukuoka, Japan |
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Abstract: | Adenomyoepithelioma is an uncommon primary breast tumor. It is conspicuous for two elements of the tumor, namely, ductal and
myoepithelial components. Recently, a Mammotome biopsy, or stereotactic vacuum-assisted biopsy has become popular and various
benign or borderline lesions are obtained. We report an adenomyoepithelioma of the breast in a 56-year-old woman. She was
pointed out to have a cluster of some microcalcifications on mammography and a 9-mm hypoechoic mass lesion was detected by
ultrasound. A Mammotome biopsy revealed a well-defined lesion. Histologically, the tumor demonstrated a thick and bi-cellular
growth pattern consisting of ducts and myoepithelium. Immunohistochemically, epithelial cells were positive for cytokeratin
AE1/AE3 and cytokeratin, epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA), negative for alpha-smooth
muscle actin (alpha-SMA). In addition, myoepithelial cells were positive for alpha-SMA and CEA, which were scatterly positive
for cytokeratin AE1/AE3, and negative for EMA. In examinations of non-palpable lesions found on mammography and ultrasound,
a Mammotome biopsy is useful for making diagnosis, however, and adenomyoepithelioma is rarely found. In diagnosing such a
rare disease from the limited information obtained from a needle biopsy, an immunohistochemical study was thus found to be
useful for making a differential diagnosis. |
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Keywords: | Adenomyoepithelioma Breast Mammotome biopsy |
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