| 肝舒乐片对非酒精性脂肪肝大鼠肝细胞线粒体能量代谢的影响 |
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| 引用本文： | 洪素兰,崔姗姗,张惠娟,邵雷. 肝舒乐片对非酒精性脂肪肝大鼠肝细胞线粒体能量代谢的影响[J]. 世界中西医结合杂志, 2010, 5(2): 111-113,116 |
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| 作者姓名： | 洪素兰 崔姗姗 张惠娟 邵雷 |
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| 作者单位： | 1. 河南省武警总队驻马店市支队卫生队,河南,驻马店,463000
2. 河南中医学院,河南,郑州,450008 |
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| 基金项目： | 河南省中医管理局资助课题 |
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| 摘 要： | 目的研究肝舒乐片对非酒精性脂肪肝(NAFL)大鼠肝细胞线粒体能量代谢的影响。方法用高脂饲料诱发大鼠NAFL模型,同时给予肝舒乐片干预,光镜下观察大鼠肝组织病理形态和琥珀酸脱氢酶(SDHase)的表达,电镜下观察肝细胞超微结构并行立体计量学分析,检测肝组织甘油三酯(TG)、总胆固醇(TC)、游离脂肪酸(FFA)含量,并与对照组比较。结果肝舒乐组的肝组织脂肪变性与肝细胞超微结构明显改善,免疫组化表明其显著促进脂肪肝肝细胞SDHase的表达,同时肝组织TG、TC、FFA含量降低,与模型组相比差异均有统计学意义(P0.05)。结论肝舒乐片能有效防治NAFL,其机理可能与增强肝细胞线粒体能量代谢有关。
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| 关 键 词： | 肝舒乐片 非酒精性脂肪肝 线粒体能量代谢 |
Impact of Ganshule Tablet on the Energetic Metabolism of Hepatocellular Mitochondria in Rats with Non-Alcoholic Fatty Liver |
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| HONG Su-lan,CUI Shan-shan,ZHANG Hui-juan,SHAO Lei. Impact of Ganshule Tablet on the Energetic Metabolism of Hepatocellular Mitochondria in Rats with Non-Alcoholic Fatty Liver[J]. World Journal Of Integrated Traditional and Wesrern Medicine, 2010, 5(2): 111-113,116 |
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| Authors: | HONG Su-lan CUI Shan-shan ZHANG Hui-juan SHAO Lei |
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| Affiliation: | HONG Su-lan1,CUI Shan-shan1,ZHANG Hui-juan2,SHAO Lei1(1. Henan College of Traditional Chinese Medicine,Zhengzhou Henan 450008,2. Health Center of Henan Force Army,Zhumadian Troop,Zhumadian Henan 463000) |
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| Abstract: | Objective To study the impact of ganshule tablet on the energetic metabolism of hepatocellular mitochondria in rats with non-alcoholic fatty liver(NAFL).Methods High-fat forage was used to induce NAFL rat model. Simultaneously,ganshule tablet was used for intervention. Under microscope,the pathological morphology of liver tissue and the expression of SDHase in rats were observed. Under electric microscope,the ultrastructure of liver cells was observed and three-dimensional metrology was performed. The conte... |
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| Keywords: | Ganshule tablet Non-alcoholic fatty liver Mitochondria energetic metabolism |
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