Immunoregulatory effects of L-arginine and therapeutical implications |
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Authors: | Potenza M A Nacci C Mitolo-Chieppa D |
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Institution: | Department of Pharmacology and Human Physiology, Section of Pharmacology, Medical School, University of Bari, Italy. potenza@farmacol.uniba.it |
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Abstract: | Arginine, initially classified as a non-essential amino acid, participates to multiple biological processes including release of several hormones, collagen synthesis during wound healing, antitumor and antibacterial activities and non-specific immunity. Nitric oxide synthase and arginase competes for L-arginine as a substrate and this event appears to play a key role in the regulation of the inflammatory process. In this framework recent studies have identified complex patterns of interactions among these enzymes. This review will emphasizes some effects of L-arginine on immune cell functions, including triggering of L-arginine-nitric oxide and arginase pathways, its biological properties and therapeutical applications. |
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