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| 炮制对何首乌主要化学成分含量的影响 | |
| 引用本文： | 张志国,吕泰省,姚庆强. 炮制对何首乌主要化学成分含量的影响[J]. 中药材, 2006, 29(10): 1017-1019 |
| 作者姓名： | 张志国 吕泰省 姚庆强 |
| 作者单位： | 1. 中国人民解放军第88医院药剂科,山东,泰安,271000;山东省医学科学院药物研究所,山东,济南,250062 2. 中国人民解放军第88医院药剂科,山东,泰安,271000 3. 山东省医学科学院药物研究所,山东 济南 250062 |
| 摘 要： | 目的:对何首乌中主要化学成分大黄素、大黄素甲醚、大黄素-8-O-β-D-吡喃葡萄糖苷、大黄素甲醚-8-O-β-D-吡喃葡萄糖苷以及2,3,5,4′-四羟基反式二苯乙烯-2-O-β-D-吡喃葡萄糖苷的含量在炮制过程中不同时间的动态变化进行研究,并分析探讨它们的变化规律。方法:采用反相高效液相色谱法,对炮制前后何首乌中5种主要成分进行含量测定。结果:所测5种成分的含量均明显降低。结论:炮制使何首乌中主要化学成分的含量均明显降低,提示临床上应用制首乌是否必要值得探讨。 |
| 关 键 词： | 何首乌 化学成分 游离蒽醌 结合蒽酯 二苯乙烯苷 反相高效液相色谱 |
| 文章编号： | 1001-4454(2006)10-1017-03 |
| 收稿时间： | 2006-01-11 |
| 修稿时间： | 2006-01-11 |
Effect of Preparation on the Major Chemical Constituents of Polygonum multiflorum |
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| ZHANG Zhi-guo,L Tai-sheng,YAO Qing-qiang. Effect of Preparation on the Major Chemical Constituents of Polygonum multiflorum[J]. Journal of Chinese medicinal materials, 2006, 29(10): 1017-1019 | |
| Authors: | ZHANG Zhi-guo L Tai-sheng YAO Qing-qiang |
| Affiliation: | Department of Pharmacy, The 88th Hospital of PLA, Tai' an 271000, China. |
| Abstract: | OBJECTIVE: To study the dynamic changes of Emodin, Physcion, Emodin-8-O-beta-D-glucopyranoside, Physcion-8-O-beta-D-glucopyranoside and 2,3,5,4'-tetrahydtoxysilbene-2-O-beta-D-glucopyranoside in Polygonum multiflorum during preparation and analyze their changing laws. METHODS: Five major constituents before and after preparation were determined by RP-HPLC methods. RESULTS: The five ingredients decreased significantly after preparation. CONCLUSION: The major chemical constituents of Polygonum multiflorum decrease significantly, suggesting the necessarity of prepared Polygonum multiflorum in clinical application worth studying. |
| Keywords: | Polygonum multiflorum Thunb. Chemical constituents Free anthraquinones Combined anthraquinones Stilbene glucoside RP-HPLC |
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