| 调心方对氧化损伤型类AD大鼠空间记忆能力和神经元钙稳态的影响 |
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| 引用本文： | 邱宏,金国琴,张学礼,戴薇薇,段艳霞,尤银珍,赵伟康,林水淼. 调心方对氧化损伤型类AD大鼠空间记忆能力和神经元钙稳态的影响[J]. 中药药理与临床, 2001, 17(5): 22-24 |
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| 作者姓名： | 邱宏 金国琴 张学礼 戴薇薇 段艳霞 尤银珍 赵伟康 林水淼 |
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| 作者单位： | 1. 上海中医药大学基础医学院,上海,200032
2. 上海中医药大学老年医学研究所 |
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| 基金项目： | 本课题为国家自然科学基金重点项目,39830450 |
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| 摘 要： | 目的：探讨调心方对氧化损伤型类AD大鼠空间学习记忆能力、脑神经元钙稳态的影响。方法：采用二羟延胡索酸（DHF）加FeCl3-ADP左侧脑室注射，造成大鼠氧化损伤型类AD大鼠模型；Morris水迷宫法观察大鼠空间学习记忆能力；荧光分光光度法测皮质和海马胞浆钙离子浓度。结果：与对照组比较，模型鼠空间学习记忆能力显下降，皮层、海马胞浆钙稳态失衡，调心方对此有明显改善作用。结论：调心方具有改善氧化损伤型类AD大鼠空间学习记忆障碍、恢复钙稳态的作用。
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| 关 键 词： | 调心方 氧化损伤型类AD 空间记忆 钙稳态 |
Effect of HBR( |
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| Qiu Hong,Jin Guoqin,Zhang Xueli,Dao Weiwei,Duan Yanxia,You Yinzhen,Zhao Weikang,Lin Shuimiao. Effect of HBR([J]. Pharmacology and Clinics of Chinese Materia Medica, 2001, 17(5): 22-24 |
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| Authors: | Qiu Hong Jin Guoqin Zhang Xueli Dao Weiwei Duan Yanxia You Yinzhen Zhao Weikang Lin Shuimiao |
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| Abstract: | To observe the effect of the Heart Benefiting Recipe (HBR) on the oxidative stress AD rats' spatial memory and calcium homeostasis in cortex and hippocampas. Methods: An oxygen free radical generation system (DHF FeCl 3 ADP) was used to create oxidative stress rat model mimic to AD; the spatial learning and memory impairment (Morris water maze method) and [Ca 2 ]i) fluorospectrophotometric method was detected; and the effect of HBR was observed. Results: Compared with normal group, model rats' spatial memory was significantly decreased, [Ca 2 ]i in cortex and hippocampas was significantly disequilibrium; HBR could improve these functions. Conclusion: HBR's effect on AD rats was related to its improving spatial memory and recovering calcium homeostasis. |
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| Keywords: | Heart Benefiting Recipe (HBR) oxidative stress AD spatial memory calcium homeostasis |
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