| 环氧乙烷遗传毒性的研究V．亚慢性吸入环氧乙烷的小鼠骨髓细胞染色体结构畸变试验 |
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| 引用本文： | 夏国兴，张龄，陆静芬，钟坤，方芳. 环氧乙烷遗传毒性的研究V．亚慢性吸入环氧乙烷的小鼠骨髓细胞染色体结构畸变试验[J]. 癌变．畸变．突变, 1995, 0(3) |
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| 作者姓名： | 夏国兴，张龄，陆静芬，钟坤，方芳 |
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| 作者单位： | 上海市卫生学校，上海职工医学院 |
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| 摘 要： | 本文观察环氧乙烷（ＥＴＯ）亚慢性吸入染毒小鼠（５４ｍｇ／ｍ３，３６Ｏｍｇ／ｍ３，２ｈ／ｄａｙ，６ｄ／Ｗｋ，／１４ｗｅｅｋ）骨髓细胞染色体结构畸变率显著高于正常对照组（４．２％Ｐ＜０．０１），５４ｍｇ／ｍ３染毒组未见显著性差异。此外，发现两组染毒小鼠骨髓细胞分裂相明显少于正常对照组，３６０ｍｇ／ｍ３浓度组细胞分裂抑制效应大于５４ｍｇ／ｍ３浓度组，细胞分裂受抑制的机理尚待探讨。
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| 关 键 词： | 环氧乙烷，染色体结构畸变，骨髓细胞分裂抑制 |
STUDY ON THE GENOT0XICITY OF ETHYLENE OXIDEV.CHROMOSOME ABERRATION OF MARROW CELLS OF MICE AFTER SUBCHRONIC INHALATION |
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| Abstract: | The chromosome aberrations of bone marrow cells in mice with subchronic inhala- tion of ethylene oxide were observed.Significant difference was found between the highestconcentration( 360 mg/m3)and control group on 2h/6day/14wk, but not in the 54 mg/m3group. On the other hand,the depressing effects of bone marrow cells division due to ethy- lene oxide,especially in the highest 360mg/m3 concentration group,was noticed also. |
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| Keywords: | ethylene oxide chroniosome structural aberration depression of marrow cells di- vision |
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