The isolation and structure elucidation of Tasiamide B,a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp |
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| Authors: | Williams Philip G Yoshida Wesley Y Moore Richard E Paul Valerie J |
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| Institution: | Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA. |
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| Abstract: | A new cytotoxic peptide, which displayed an IC(50) value of 0.8 microM against KB cells, has been isolated from the marine cyanobacterium Symploca sp. The planar structure of tasiamide B (1), deduced by 2D NMR experiments, contains the unusual amino acid-derived residue 4-amino-3-hydroxy-5-phenylpentanoic acid (Ahppa). The configuration of 1 was deduced by HPLC analysis of degradation products. |
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