Insulin-like growth factor 1 (IGF-1) and growth hormone (hGH) as the markers of osteoarthritis

AIM OF STUDY: The aim of study was evaluation of diagnostic usefulness of IGF-1 and hGH serum level in osteoarthritis. MATERIAL AND METHODS: IGF-1 and hGH concentration were measured in serum collected from 25 patients with coxarthrosis and 16 healthy persons. IGF-1 and hGH serum level were assayed by ELISA. RESULTS: There was no statistics difference in growth hormone serum level between osteoarthritis patients and healthy persons. The ROC curve for hGH concentration confirmed low discriminatory value of this test. There was no significant correlation between hGH and IGF-1 in serum. IGF-1 concentration in patients serum was significant lower then in control grupe. The ROC curve for serum level of IGF-1 confirmed significant usefulness this test in laboratory diagnostic of osteoarthritis. CONCLUSIONS: Serum concentration of IGF-1 seems to be usefull laboratory marker of osteoarthritis.