Synthesis of Dimeric Quinazolin‐2‐one, 1,4‐Benzodiazepin‐2‐one,and Isoalloxazine Compounds as Inhibitors of Amyloid Peptides Association

The synthesis of dimeric compounds derived from quinazolin‐2‐one and 1,4‐benzodiazepin‐2‐one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis‐isoalloxazine and a bis‐riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer‐specific Aβ peptides was investigated using a fast screening system based on flow cytometry. The bis‐isoalloxazine 14 was identified as a new lead structure.