Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues |
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| Authors: | Wen Lu Liu Jian Cun Zhang Fa Qin Jiang Lei Fu |
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| Affiliation: | 1. School of Pharmacy, Shanghai Jiaotong University, Shanghai, P.R. China. Fax: +86 21 3420‐4787;2. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P.R. China |
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| Abstract: | Two analogues of cryptophycin were synthesized and biologically evaluated for their in‐vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC50 values in the μM‐range, and compound 4 was more effective than compound 3 in most assays studied. |
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| Keywords: | Anticancer Cryptophycin Cytotoxicity Synthesis Taxol |
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