Role of endogenous testosterone concentration in pediatric stroke |
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| Authors: | Sandra Normann MD Gabrielle de Veber MD Manfred Fobker MD Claus Langer PhD Gili Kenet MD Timothy J. Bernard MD Barbara Fiedler MD Ronald Sträter MD Neil A. Goldenberg MD PhD Ulrike Nowak‐Göttl MD |
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| Affiliation: | 1. Department of Pediatric Hematology/Oncology, University Children's Hospital, University of Münster, Münster,Germany;2. Department of Neurology, Hospital for Sick Children, Toronto, Canada;3. Department of Laboratory Medicine, University Hospital, Münster, Germany;4. The Israel National Hemophilia Center, Sheba Medical Center, Tel‐Hashomer, Israel;5. The Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado, Denver, CO;6. The Children's Hospital, Aurora, CO;7. Department of Pediatric Neurology, University Children's Hospital, Münster, Germany |
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| Abstract: | Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38–11.45]; AIS = 3.88 [1.13–13.35]; CSVT = 5.50 [1.65–18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3‐fold. Ann Neurol 2009;66:754–758 |
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