Successful cell‐mediated cytokine‐activated immunotherapy for relapsed acute myeloid leukemia after hematopoietic stem cell transplantation |
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| Authors: | Benjamin Gesundheit Michael Y. Shapira Igor B. Resnick Avraham Amar Don Kristt Lilianne Dray Einat Budowski Reuven Or |
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| Affiliation: | 1. Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, Jerusalem, Israel;2. Tissue Typing Unit, Department of Hematology, Hadassah University Hospital, Jerusalem, Israel;3. Laboratory of Histocompatibility and Immunogenetics, Department of Pathology, Sackler School of Medicine, Rabin Medical Center, Tel‐Aviv University, Petach Tikvah, Israel |
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| Abstract: | Acute myeloid leukemia (AML) is an extremely aggressive disease with a high relapse rate even after allogeneic hematopoietic stem cell transplantation (HSCT). We report the successful outcome of cell‐mediated cytokine‐activated immunotherapy in a high‐risk pediatric AML patient who relapsed shortly after allogeneic HSCT. Donor lymphocyte infusion along with interferon induced a graft‐versus‐leukemia effect, presenting as a reversible episode of graft‐versus‐host disease, which led to stable complete donor chimerism and total eradication of AML for over 24 months, at the time of this report. The curative potential of immunotherapy in hematological malignancies is discussed. Am. J. Hematol., 2009. © 2008 Wiley‐Liss, Inc. |
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