Synthesis and Cytotoxicity Screening of Piperazine‐1‐carbodithioate Derivatives of 2‐Substituted Quinazolin‐4(3H)‐ones |
| |
| Authors: | Sheng‐Li Cao Yan‐Wen Guo Xian‐Bo Wang Mei Zhang Yu‐Ping Feng Yu‐Yang Jiang Yue Wang Qian Gao Jian Ren |
| |
| Affiliation: | 1. School of Science, Beijing Technology Institute, Beijing, China;2. Department of Chemistry, Capital Normal University, Beijing, China. Fax: +86 10 68902493;3. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education;4. Department of Chemistry, Tsinghua University, Beijing, China;5. Key Laboratory of Chemical Biology, Guangdong Province;6. Graduate School at Shenzhen, Tsinghua University, Shenzhen, China |
| |
| Abstract: | A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3H)‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported. |
| |
| Keywords: | Dithiocarbamate Cytotoxicity Quinazolin‐4(3H)‐one Screening Synthesis |
|
|
