Novel lβ‐Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in‐vitro Biological Activity – Part II |
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| Authors: | Seong Jong Kim Jung‐Hyuck Cho Chang‐Hyun Oh |
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| Affiliation: | Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, Korea. Fax: +82 2 958‐5189 |
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| Abstract: | The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular compound IIIe having a [1,2,5]thiadiazolidin 1,1‐dioxide moiety showed the most potent antibacterial activity. |
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| Keywords: | Antibacterial activity 1β ‐Methylcarbapenems Substituent effects |
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