Demyelination Induces the Decline of the Myelinated Fiber Length in Aged Rat White Matter |
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| Authors: | Chen Li Shu Yang Wei Zhang Wei Lu Jens R Nyengaard John H Morrison Yong Tang |
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| Institution: | 1. Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China;2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China;3. Chen Li and Shu Yang are co‐first authors.;4. Stereology and Electron Microscopy Research Laboratory and MIND Center, Aarhus University, Aarhus, Denmark;5. Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York |
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| Abstract: | To determine the exact reason for the age‐related decline of the myelinated fiber length in white matter, we performed this study. In middle‐aged rats, there was age‐related loss of the unmyelinated fibers with large diameters. The demyelination of the myelinated fibers with small diameters in middle‐aged rat white matter might make the age‐related decrease of the unmyelinated fibers with small diameters in the white matter unnoticeable. However, in old‐aged female rats, the unmyelinated fibers with large and small diameters significantly degenerated together and that the unmyelinated fibers formed from the demyelination of the myelinated fibers could not replenish the age‐related loss of the unmyelinated fibers in the white matter. In conclusion, this study suggested that demyelination of myelinated fibers with small diameters in aged white matter might be the key mechanism of the significant decline of the myelinated fiber length in aged white matter. Anat Rec, 292:528–535, 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | myelinated fibers unmyelinated fibers white matter aging stereology |
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