Application of depression criteria (DSM-IV) in patients with Parkinson's disease |
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Authors: | Juan Carlos Gmez-Esteban Beatriz Tijero Johanne Somme Iker Bilbao Julen Fernndez Sabas Boyero Fernando Velasco Elena Lezcano JJ Zarranz |
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Institution: | aMovement Disorders Unit, Department of Neurology, Hospital of Cruces, Baracaldo Vizcaya, Osakidetza-Servicio Vasco de Salud, Spain;bDepartment of Psychiatry, Hospital of Cruces, Baracaldo Vizcaya, Osakidetza-Servicio Vasco de Salud, Spain |
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Abstract: | IntroductionThe aim of this study is to analyze the clinical differences between Parkinson's disease patients with major (MD) and minor depression (md) and to see how both affect the quality of life.Material and methods118 patients diagnosed with Parkinson's disease. The mean age of onset was 60.4 ± 11.2 years with a mean duration of 8.5 ± 6.2 years. Depression was diagnosed according to DSM-IV-TR criteria. Scores on the Hamilton depression inventory, MMSE, PDQ-39, NPI-10, UPDRS III, and UPDRS IV were recorded.ResultsTwenty-one patients (17.8%) met the criteria of major depression (MD) and 33 (28.0%) those of minor depression (md). The scores on the PDQ-39 and NPI-10 of patients with MD were higher than in patients with md, and control group. The MMSE scores were lower in patients with MD. In 52.2% of the patients with MD, the diagnosis of depression was made prior to that of PD, this occurred only in 24.2% of the patients with md (p < 0.001). The presence of anhedonia was related to cognitive impairment and the presence of neuropsychiatric symptoms.DiscussionMD is probably a part of the disease process of PD; it is associated with cognitive impairment and may precede motor symptoms. |
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Keywords: | Parkinson disease Major depression Minor depression Quality of life Cognitive impairment Neuropsychiatric symptoms |
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