2型糖尿病脂联素水平变化的意义及多因素分析

目的观察2型糖尿病(T2DM)患者脂联素水平变化,比较不同体重指数(BMI)者脂联素水平差异,探讨其与糖尿病的关系,并对受其影响的相关因素进行相关性分析。方法将77例T2DM患者分为非肥胖组26例(NF组),肥胖组51例(F组)。另取18例正常体检者作为对照(N组)。分别采用ELISA法检测脂联素,放射免疫法检测连接肽(CP),采用TOSHIBA TBA-120FR全自动生化仪检测空腹血糖(FPG)、血脂、C反应蛋白(CRP)。结果所有T2DM患者血浆脂联素水平均显著低于正常人(P<0.01);F组血浆脂联素明显低于NF组(P<0.01);简单典型相关性分析结果显示,除NF组脂联素与MBp无显著相关性,F组和所有T2DM者的脂联素与TG及FPG亦无显著相关性之外,其他因素与脂联素均呈显著负性相关(P<0.01)。多元线性回归分析结果显示,所有T2DM者LDLC、CP、MBp与脂联素相互影响有显著性意义(P<0.05或0.01);NF组LDL-C、CP、BMI与其相互影响意义有显著性(P<0.05);而F组LDL-C、BMI、MBp与其相互影响有显著性意义(P<0.05或0.01)。结论血浆脂联素水平降低是T2DM、高血脂、肥胖、高血压的重要危险因素,血浆脂联素在T2DM、高血压、高血脂等发病中起重要作用。

The variances of adiponectin and the associating factors analysis in patients with type 2 diabetes mellitus

Objective To study the variances of adiponectin in patients with type 2 diabetes mellitus(T2DM),compared them by body mass index(BMI) and investigate the relation with diabetes,then detected the serum levels of adiponectin and analysed the associating factors.Methods 77 patients with T2DM were divided into two groups according to BMI:26 not fleshiness cases(group NF) and 51 fleshiness cases(group F).And there were 18 normal cases in control group.To all the cases,serum adiponectin were detected by ELISA;low density lipoprotein cholesterol(LDLC),triglyceride(TG),C-reactive protein(CRP),fasting plasma glucose(FPG) were detected by TOSHIBA TBA-120FR automatically biochemical analyzer;connective peptide(CP) were detected by immunoradiometric assay(IRMA).Results Serum adiponetin levels in patients with T2DM were significant lower than those of normal cases(P<0.01),And those in group F were significant lower than group NF.Under multiple linear regression analyze,Adiponetin levels are negatively correlated with LDL-C,CRP,CP,BMI and MBp in patients with T2DM(P<0.01),negatively correlated with LDL-C,TG,CP,BMI,FPG in group NF(P<0.01),but negatively correlated with LDL-C,CRP,CP,BMI,MBp in group F(P<0.05or0.01).Conclusion Decreasing serum adiponectin level could be a risk factor of T2DM,hyperlipidemia,hypertension and over fat.Adiponectin plays a very important role in the mechanism of T2DM,hyperlipidemia and hypertension.