无症状性颈内动脉狭窄与认知功能障碍的相关性研究

目的：探讨无症状性颈内动脉狭窄与认知功能障碍的关系。方法筛选本院的住院、门诊及健康查体者150例，其中颈内动脉狭窄组90例，对照组60例，颈内动脉狭窄组应用颈动脉彩超检查，狭窄程度轻、中、重度者分别为35例、29例、26例。用简易精神状态量表（MMSE）对认知功能进行评价，观察患者颈动脉不同狭窄程度与认知功能的关系。结果颈内动脉狭窄组MMSE评分低于对照组，差异有统计学意义（P〈0.01）。颈内动脉狭窄组各组MMSE评分两两比较，差异有统计学意义（P〈0.05）；颈内动脉狭窄程度与认知功能MMSE评分呈负相关，即颈内动脉狭窄越重，MMSE评分越差，认知功能障碍越严重。结论颈内动脉狭窄者存在认知功能障碍，狭窄程度与认知障碍严重程度具有相关性，随着颈内动脉狭窄程度增加，认知功能障碍加重。

Correlation study of asymptomatic internal carotid artery stenosis and cognitive disorder

Objective To discuss the relationship between asymptomatic internal carotid artery stenosis （ICAS） and cognitive disorder. Methods One hundred and fifty cases from inpatients,outpatients,and healthy people after physical examinations were selected,of whom,90 patietns were as ICAS group and 60 cases were as control group.In the ICAS group,the number of stenosis in mild,medium,and severe degrees were 35,29,and 26 respectively after carotid color ul-trasonography.Cognitive function was evaluated by mini-mental state examination （MMSE）.The relationship between carotid artery stenosis in different degrees and cognitive function was observed. Results The MMSE score in the ICAS group was lower than that in the control group,the difference was significant （P〈0.01）.The MMSE scores displayed sig-nificant differences in the ICAS group after comparison between any two groups （P〈0.05）.Stenosis degree of carotid artery had a negative relationship with MMSE score in cognitive function.That’s to say,the more severe of ICAS was,the poorer MMSE score was and the more serious cognitive disorder became. Conclusion Patients with ICAS has cognitive disorders,and degree of stenosis is related to the severity of cognitive disorder.With the increasing degree of ICAS,cog-nitive disorder aggravates.