正脂丸抗氧化、保护血管内皮功能作用的研究

目的：观察正脂丸防止动脉粥样硬化(As)形成的作用并探讨其可能的作用机制，方法：18例家兔随机分为3组（空白对照组、模型组、正脂丸组），分别于实验前、实验8w后测定血清总胆固醇（TC）、氧化低密度脂蛋白(ox-LDL)和NO含量，8w后处死动物，测定主动脉粥样硬化斑块面积，主动脉分支开口处斑块形成率及心壁内冠状动脉分支狭窄程度，结果：8w后正脂丸组血清TC，ox-LDL水平明显低于模型组，NO高于模型组（P＜0．05），主动脉斑块面积，心壁内冠状动脉分支狭窄程度均明显小于模型组。，结论：正脂丸有较好的防止As形成的作用，作用机制除降低血清TC含量处，还与其防止LDL氧化，保护血管内皮功能有关。

Effect of Zhengzhi Pill on Anti - Oxid and Protecting Endotheli Cell

to investigate the antiatherogenetic effect of Zhengzhi pellet(zzp)and discuss its mechanisms. methods Eighteen rabbits were divided randomly into three groups and fed with common forage, high lipid forage, high lipid forage adding zzp, respectively. serum total cholesterol (TC) and ox-LDL, NO was detected at the o and 8th week. at the end of the eighth week, aorta and heart were obtained for measurement of mean plaque area in aorta and degree of stenosis of coronary ateries. results after 8 weeks, serum TC and ox-LDL in zzp group animals were significantly lower than that in the model group (P<0 05). NO level was significantly higher than that in model group (P<0 05). zzp could decrease the mean plaque area of aorta. The degree of stenosis of coronary artery branches in the heart wall of the zzp group was much less than that of the model group. conclusions zzp can prevent atherogenesis. apart from decreasing serum TC, the mechanisms may be correlated with its antilipoperioxide action and protection of endothelial cell.