微囊藻毒素LR对小鼠的急性毒性研究

目的 了解微囊藻毒素对小鼠的急性损伤作用.方法 以BALB/C小鼠为材料,腹腔注射μg./kg·b.w.和43μg/kg·b.w.剂量的微囊藻毒素LR,测定脏器系数和一系列生化指标.结果 肾脏指数与肝脏指数明显增加,表明两种器官都受到损伤;血清中天冬氨酸转氨和丙氨酸转氨酶活力上升,尿素含量下降预示着肝脏损伤,尿酸含量上升则预示肾脏损伤的发生.结论 肾脏也可能是易受微囊藻毒素损伤的器官.

Acute toxicity of microcystin-LR in BALB/c mice

Objective To investigate acute toxicity of microcystin-LR in BALB/c mice. Methods BALB/c mice were subjected to intraperitoneal injection of microcystin-LR at the half lethal dose (LD50) and 1/2 LD50, and the organ weight indices and various biochemical indices were determined 30 min and 4 h after the treatment, respectively. Results Significant increase in liver or kidney weight index occurred in the treated mice, indicating hemorrhagic conditions of the two organs. A slight increase in serum levels of aspartate amino transferase and alanine aminotransferase was observed along with an obvious decrease in serum urea levels, suggesting liver damage. The increase of serum uric acid also indicated the presence of kidney damage. Conclusion The kidney may be another target of microcystins besides the liver.