脑出血患者血浆MMP-2、MMP-9变化的临床研究

目的 探讨脑出血（ICH）患者血浆MMP-2、MMP-9含量及临床意义。方法 分别测定50例ICH患者和50例健康人血浆中MMP-2、MMP-9的含量。结果 脑出血组患者血浆MMP-2、MMP-9上升，与正常对照组比较差异有高度统计学意义（P〈0．01）；MMP-2、MMP-9在轻、中、重型组之间比较差异均有高度统计学意义（P〈0．01）；在不同发病时间组中的MMP-9含量比较差异具有高度统计学意义（P〈0．01）；MMP-2在6h组与12h组比较差异无统计学意义（P〉0．05），在其他时间组比较差异有高度统计学意义（P〈0．01）；不同血肿体积组中MMP-2、MMP-9含量比较差异均有高度统计学意义（P〈0．01）。结论 ICH患者MMP-2、MMP-9水平与血肿体积、发病时间和神经功能缺失程度都具有密切关系，可作为判定病情和评估预后的参考指标。

Changes of plasma metalloproteinase-2 and metalloproteinase- 9 in patients with intracerebral hemorrhage

Objective To investigate the changes and the significance of the contents in matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in plasm of patients with intracerebral hemorrhage (ICH). Methods The contents of MMP-2 and MMP-9 in plasm of 50 patients with ICH and 50 healthy people (control group) were measured respectively through ELISA methods. Results Compared with the control group,the increase of the contents of MMP-2 and MMP-9 had obvious statistic significance in plasm of patients with ICH (P<0.01);Between any two of the three degrees:easy,middle and serious degree,the changes of the contents of MMP-2 and MMP-9 had obvious statistic significance (P<0.01).The changes of the contents of MMP-9 in different time had statistic obvious significance (P<0.01).The changes of the contents of MMP-2 had not statistic significance between the 6 h and the 12 h group(P>0.05),but they had obvious statistic significance in the comparison among other time groups (P<0.01).The changes of the contents of MMP-2 and MMP-9 in different hematoma volumes had obvious statistic significance (P<0.01). Conclusion The changes of the contents of MMP-2 and MMP-9 in plasm of patients with ICH are closely related with hematoma volume,time and degree of nervous function injury.It would be an important factor to judge the grade of disease and evaluate the prognosis.