| 醒脑静注射液治疗急性脑梗死伴意识障碍的疗效观察 |
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| 引用本文： | 朱旭莹,方正龙,顾国柱,李超生.醒脑静注射液治疗急性脑梗死伴意识障碍的疗效观察[J].内科理论与实践,2009,4(3):209-211. |
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| 作者姓名： | 朱旭莹 方正龙 顾国柱 李超生 |
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| 作者单位： | 上海市中医药大学附属曙光医院神经内科; |
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| 摘 要： | 目的:观察醒脑静注射液治疗急性脑梗死伴意识障碍患者的临床疗效。方法:将106例患者随机分为2组,对照组(50例)采用常规脱水剂、阿司匹林及丹参注射液治疗,治疗组(56例)在对照组治疗基础上加用醒脑静注射液静脉滴注,疗程14d。观察2组格拉斯哥昏迷(GCS)评分、美国国立卫生研究院脑卒中量表(NIHSS)评分、内皮素(ET)和血清一氧化氮(NO)的变化。结果:2组治疗后的GCS和NIHSS评分均优于治疗前(P<0.05),且评分的分值在2组间均有显著差异(P<0.05);治疗组治疗14d后GCS评分和21d后NIHSS评分的改善程度均优于对照组(差值分别为5.58±1.87比6.62±1.67和-4.50±1.29比-5.42±1.67,均P<0.05);经14d治疗,2组ET浓度较治疗前显著降低(P<0.05),血清NO浓度较治疗前显著升高(P<0.05),组间比较亦有明显差异(P<0.05)。结论:在常规治疗的基础上加用醒脑静注射液可显著影响脑梗死患者ET的下降幅度及NO的上升水平,提高GCS评分,促进患者的意识功能恢复,进一步降低脑梗死患者神经功能缺损的NIHSS评分,改善患者的神经功能,使急性脑梗死伴意识障碍的疗效更好。
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| 关 键 词： | 醒脑静注射液 脑梗死 意识障碍 内皮素 一氧化氮 |
Clinical effect of Xingnaojing injection in treatment of cerebral infarction with conscious disturbance |
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| ZHU Xu-ying,FANG Zheng-long,GU Guo-zhu,Li Chao-sheng.Clinical effect of Xingnaojing injection in treatment of cerebral infarction with conscious disturbance[J].Joournal of Internal Medicine Concepts& Practice,2009,4(3):209-211. |
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| Authors: | ZHU Xu-ying FANG Zheng-long GU Guo-zhu Li Chao-sheng |
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| Institution: | ZHU Xu-ying,FANG Zheng-long,GU Guo-zhu,LI Chao-sheng. Department of Neurology,Shuguang Hospital Affiliated with Shanghai University of Chinese Traditional Medicine,Shanghai 200021,China |
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| Abstract: | Objective To observe the clinical effect of Xingnaojing injection in the treatment of cerebral infarction with conscious disturbance. Methods A hundred and six patients with cerebral infarction were randomly divided into two groups:50 cases in the control group were treated with dehydration agents,aspirin and Danshen injection; 56 cases in the treatment group were treated with Xingnaojing injection,with a course of 14 d,in addition to the basic treatment as in control group. The Glasgow coma scale (GCS) sco... |
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| Keywords: | Xingnaojing injection Cerebral infarction Conscious disturbance Endothelium Nitrogen monoxidum |
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