| FK506免疫抑制机理的研究 |
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| 引用本文： | 蔡仙德,穆维同.FK506免疫抑制机理的研究[J].中华器官移植杂志,1995,16(1):36-38. |
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| 作者姓名： | 蔡仙德 穆维同 |
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| 作者单位： | 南京铁道医学院微生物学教研室，南京大学医学院微生物教研室 |
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| 摘 要： | 通过采用淋巴细胞增殖试验，混合淋巴细胞反庆和间接免疫荧光法分析淋巴细胞表面白细胞介素２受体（ＩＬ－２Ｒ）和ＴｆＲ的表达，研究了ＦＫ５０６的免疫抑制作用。结果表明，ＦＫ５０６对植物血凝素（ＰＨＡ）诱导的淋巴细胞增殖具有强烈的抑制作用，５０％抑制浓度＊ＩＣ５０）为１．３５ｎｍｏｌ／Ｌ，外源性ＩＬ－２不能逆转这种作用；对混合淋巴细胞反应（ＭＬＲ）有显著抑制作用，其ＩＣ５０为０．１２ｎｍｏｌ／Ｌ；在由ＰＨ
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| 关 键 词： | FK506 淋巴细胞 白细胞介素2 受体 移植免疫学 |
Research on the immunosuppressive mechanism of FK506 |
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| Cai Xiande,Mu Weitong,Tan Jianping,.Research on the immunosuppressive mechanism of FK506[J].Chinese Journal of Organ Transplantation,1995,16(1):36-38. |
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| Authors: | Cai Xiande Mu Weitong Tan Jianping |
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| Abstract: | The effect of FK506 on PHA-and alloantigen-induced human peripheral blood lymphocyte Proliferation,expressions of IL-2R and TfR were investigated by the methods of 3H-TdR incorporation and indirect immunofluorescence respectively. The results demonstrated that FK506 had an inhibitory effect on PHA-induced proliferation (IC50 13.5 nmol/ L), which could not reversed by exogenous recombinant IL-2. In both PHA-stimulants and alloactivated lymphocytes, FK506 could inhibit the expressions of TfR and IL-2R.This study sugguested that FK506 was an effective immunosuppressive agent. |
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| Keywords: | FK506 Mixed lymphocytes reaction interleukin-2 receptor |
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