不同种质子泵抑制剂组成短程三联疗法根除幽门螺杆菌的比较

目的比较不同种类的质子泵抑制剂(PPI)在相同条件下的抗幽门螺杆菌(HP)的效果及对胃、十二指肠溃疡的治疗效果。方法240例幽门螺杆菌(HP)阳性的胃、十二指肠溃疡病人和慢性胃炎病人随机分成4组,每组60例,分别以奥美拉唑(O)、兰索拉唑(L)、潘妥拉唑(P)、雷贝拉唑(R)4种PPI制剂与阿莫西林(A)和克拉霉素(C)组成三联疗法进行抗HP治疗,疗程7d。慢性胃炎病人停药至少4周后复查;胃、十二指肠溃疡病人结束溃疡治疗至少4周后复查。复查内容包括胃镜检查取胃黏膜作快速尿素酶试验(RUT)、组织学检查(改良美式试验),和13C-尿素呼气检查(13C-UBT)。三项均为阴性者为HP根除。胃和十二指肠溃疡病人同时评判溃疡愈合情况。结果4组抗HP治疗结果以卡方检验进行比较,发现R组与P组间差异存在非常显著意义(P<0.01),其他各组间差异无显著意义(P>0.05)。各治疗组溃疡愈合率差异无显著意义。结论含雷贝拉唑的三联方案HP根除率较高;兰索拉唑抑酸起效较快,更适合作为短程方案使用。

Comparison of effects of different proton pump inhibitors on helicobacter pylori and peptic ulcer

ObjectiveTo compare the effects of different proton pump inhibitors (PPI) in the same condition on helicobacter pylori (HP) and peptic ulcer.MethodsTwo hundred and forty patients with gastric,duodenal ulcer or chronic gastritis were divided into four groups:omeprazole (O),lansoprazole(L),pantoprazole(P) and rabeprazole (R) group.The patients in each group (60 cases) were received respectively one of above-mentioned PPI,amoxicillin (A) and clarithromycin (C).The course of treatment were 7 days.Follow-up examination were cavried out in 4 weeks after treatment. In the patients with eradication of HP,rapid ures test ,histological examination of gastric mucosa,and ~(13)C-urea breathing test were all nagative.Results The radical rate of HP in R group was higher than that in P group(P<0.01),but there was no significant differences among other groups (P>0.05).Conclusion The radical rate of HP using triple project containing rabeprazole is higher.