夹竹桃乙素的药理性质及与g-毒毛旋花子甙、異羟基洋地黄毒甙、洋地黄毒甙的比较研究

夹竹桃乙素是夹竹桃叶中所含的主要强心成分.本文证明其药理性质不同于g-毒毛旋花子甙和洋地黄毒甙,而与异羟基洋地黄毒甙(digoxin)相近.具有较小的蓄积作用和较大的口服吸收率,以及较强的生物活性.作者认为临床上可用以代异羟基洋地黄毒甙使用.

THE PHARMACOLOGY OF OLEANDRIN COMPARED WITH g-STROPHANTHIN, DIGOXIN AND DIGITOXIN

Oleandrin is a cardiac glycoside isolated from the leaves of Nerium oleander L. Our experiments indicated that the pharmacology of oleandrin was different from that of g-strophanthin or digitoxin but similar to those of digoxin in some respects. Oleandrin was found to be less cumulative in action and better absorbed than digoxin following an oral administration. Oleandrin showed a stronger biological activity than digoxin and digitoxin. It is suggested that oleandrin may be tried clinically where digoxin or des- lanoside is needed.