Quality of life (QoL) in community-dwelling and institutionalized Alzheimer's disease (AD) patients |
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| Affiliation: | 1. Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Valderrebollo 5, 28031 Madrid, Spain;2. Maria Wolff Foundation, Río Sil 15, 28669 Madrid, Spain;3. Mental Health Center of Colmenar Viejo (Hospital La Paz), Cecilio de la Morena Arranz 2, 28770 Madrid, Spain;4. CIBERNED, Carlos III Institute of Health, Madrid, Spain;1. Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada;2. Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada;3. Westpark Healthcare Centre, Toronto, ON, Canada;1. Department of Respiratory Medicine, City Hospital Campus, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK;2. Respiratory and Systemic Infection Laboratory, Public Health England, Microbiology Services Division, Colindale Avenue, London NW9 5EQ, UK;3. Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK;1. Department of Mathematics, Louisiana State University, Baton Rouge, LA USA;2. Department of Experimental Statistics, Louisiana State University, Baton Rouge, LA USA;1. Department of Internal Medicine B, Assaf Harofeh Medical Center, Zerifin 70300, Israel;2. Department of Internal Medicine F, Assaf Harofeh Medical Center, Zerifin 70300, Israel;3. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel;1. Medical Psychology | Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), University Hospital Cologne, Kerpenerstraße 62, 50937 Cologne, Germany;2. Institute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Albertus-Magnus-Platz, 50923 Cologne, Germany;3. Institute of Gerontology, University of Vechta, Driverstraße 22, 49377 Vechta, Germany |
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| Abstract: | The purpose of this study was to describe and compare QoL and its determinants in two groups of patients with AD that differed in place of residence: community or nursing home. This study covered 200 patients with AD (mean age 79.3 ± 8.2 years, 74% female). Fifty-four per cent of the subjects were living in a nursing home and 46% lived at home. QoL was measured using the Alzheimer's Disease Related Quality of Life Scale (ADRQL). The ADRQL was answered by the family caregiver (community group) or the professional caregiver (nursing home group). Descriptive statistics, Chi-square test, Mann–Whitney test and multiple regression analysis were used to compare sociodemographic and clinical variables between the two study groups. The institutionalized patients were predominantly women (87.0% vs. 58.7%, p < 0.001), were older (84 years vs. 74 years, p < 0.001), and had more advanced dementia (Global Deterioration Scale (GDS) > 5 79.6% vs. 19.6%, p < 0.001). ADRQL total score was higher (i.e., better QoL) for patients living at home than for institutionalized patients (72.6 ± 19.9 vs. 64.8 ± 18.2, p < 0.01). Neuropsychiatric symptoms, severity of dementia, depression and functional dependence were significant predictors of worst QoL. Once those variables were controlled a marginal effect of setting on QoL was found, which favored the nursing home (β = 0.20, p < 0.05). |
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| Keywords: | QoL Community Nursing home Dementia Behavioral symptoms Severity of dementia Functional dependence |
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