基质金属蛋白酶及组织金属蛋白酶抑制剂在鼻腔鳞状细胞癌中的表达及意义

目的 研究基质金属蛋白酶(matrix metalloproteinase,MMP)2、MMP-9及组织金属蛋白酶抑制剂(tissue inhibitor of metalloproteinase,TIMP)1、TIMP-2在鼻腔鳞状细胞癌中的表达及意义.方法 应用免疫组化S-P法检测50例鼻腔鳞状细胞癌和50例中鼻甲...

Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma

Objective To study the expression and significance of matrix metalloproteinase (MMP)2, MMP-9, tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP-2 in nasal cavity squamous cell carcinoma and their signification. Methods Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasal tissue were detected for MMP-2, MMP-9, TIMP-1, TIMP-2 by immunohistochemistry technique (S-P), and their relationship between the expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and some clinical symptoms were analyzed. The SPSS 12. 0 software was used to analyze the data. Results The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52. 0% (26/50), which was significantly higher ( x2 = 6. 00, P ＜0. 05 ) than those [28.0% (14/50)] in the normal nasal tissue. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% (29/50), which was significantly higher ( x2 = 12. 8, P ＜ 0. 05 ) than those [10. 0% (5/50)] in the normal nasal tissue. The positive ratio of expression of TIMP-1 in two groups was 74. 0% (37/50), 56. 0% (28/50) respectively.There was no difference between two groups ( x2 = 0. 51, P ＞ 0. 05 ). The positive ratio of expression of TIMP-2 in two groups was 26. 0% ( 13/50), 20% (10/50) respectively. There was no difference between two groups( x2 = 3.35, P ＞ 0. 05). Conclusions There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. Both MMP and TIMP, especially the unbalance of MMP and TIMP, have prognostic value in nasal cavity squamous cell carcinoma.