| PiWil2在甲状腺乳头状癌中的表达及其与侵袭转移的关系 |
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| 引用本文： | 殷德涛,李红强,王勇飞,曹胜利,周玉冰,郑立运,江金花,王庆端.PiWil2在甲状腺乳头状癌中的表达及其与侵袭转移的关系[J].中华耳鼻咽喉头颈外科杂志,2011,46(3). |
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| 作者姓名： | 殷德涛 李红强 王勇飞 曹胜利 周玉冰 郑立运 江金花 王庆端 |
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| 作者单位： | 河南省高等学校临床医学重点学科开放实验室,郑州大学第一附属医院甲状腺外科,450052 |
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| 摘 要： | 目的 探讨piwil2在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)中的表达及其与PTC的关系.方法 采用免疫组化、原位杂交检测60例PTC患者肿瘤组织及其癌旁组织中Piwil2蛋白和piwil2 mRNA的表达情况.结果 Piwil2蛋白在肿瘤组织和癌旁组织中的阳性表达率分别为8 8.3%(53/60)和10.0%(6/60),两者比较差异有统计学意义(x2=73.654,P＜0.01).piwil2 mRNA在肿瘤组织和癌旁组织中的阳性表达率分别为85.0%(51/60)和6.7%(4/60),两者比较差异有统计学意义(x2=74.148,P＜0.01).Piwil2蛋白及mRNA在PTC中的表达与患者的TNM分期及淋巴转移有关(P值均＜0.05).Piwil2蛋白及mRNA在PTC中的表达有相关性(x2=15.098,P＜0.01).结论 Piwil2参与了PTC的发生发展,与PTC的浸润和颈淋巴转移有关.Abstract：Objective To study the expressions of Piwil2 protein and mRNA in papillary thyroid carcinoma(PTC) and the relationship between Piwil2 and the invasion and metastasis of PTC. Methods Immunohistochemistry and in situ hybridization were used to detect the expression of Piwil2 protein and mRNA in 60 cases of PTC with the matched adjacent non-cancerous epithelium (NCE). Results The positive rates of Piwil2 protein expression in PTC and NCE were 88.3% (53/60) and 10.0% (6/60)respectively, with significant difference ( x2 = 73. 654,P ＜ 0.01 ). The positive rates of Piwil2 mRNA expression in PTC and NCE were 85.0% (51/60) and 6. 7% (4/60) respectively, also with significant difference (x2 =74. 148 ,P ＜0.01 ). Up-regulated expressions of Piwil2 protein and mRNA were related to the invasion and metastasis of PTC (P ＜ 0.05 ). Conclusion Piwil2 may play a role in the invasion and metastasis of PTC.
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| 关 键 词： | 甲状腺肿瘤 癌 乳头状 原位杂交 蛋白质类 |
Expression of Piwil2 and its relationship with tumor invasion and metastasis in papillary thyroid carcinoma |
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| YIN De-tao,LI Hong-qiang,WANG Yong-fei,CAO Sheng-li,ZHOU Yu-bing,ZHENG Li-yun,JIANG Jin-hua,WANG Qing-duan.Expression of Piwil2 and its relationship with tumor invasion and metastasis in papillary thyroid carcinoma[J].Chinese JOurnal of Otorhinolaryngology Head and Neck Surgery,2011,46(3). |
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| Authors: | YIN De-tao LI Hong-qiang WANG Yong-fei CAO Sheng-li ZHOU Yu-bing ZHENG Li-yun JIANG Jin-hua WANG Qing-duan |
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| Abstract: | Objective To study the expressions of Piwil2 protein and mRNA in papillary thyroid carcinoma(PTC) and the relationship between Piwil2 and the invasion and metastasis of PTC. Methods Immunohistochemistry and in situ hybridization were used to detect the expression of Piwil2 protein and mRNA in 60 cases of PTC with the matched adjacent non-cancerous epithelium (NCE). Results The positive rates of Piwil2 protein expression in PTC and NCE were 88.3% (53/60) and 10.0% (6/60)respectively, with significant difference ( x2 = 73. 654,P ＜ 0.01 ). The positive rates of Piwil2 mRNA expression in PTC and NCE were 85.0% (51/60) and 6. 7% (4/60) respectively, also with significant difference (x2 =74. 148 ,P ＜0.01 ). Up-regulated expressions of Piwil2 protein and mRNA were related to the invasion and metastasis of PTC (P ＜ 0.05 ). Conclusion Piwil2 may play a role in the invasion and metastasis of PTC. |
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| Keywords: | Thyroid neoplasms Carcinoma papillary In situ hybridization Proteins |
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