血尿酸水平和儿童阻塞性睡眠呼吸暂停/低通气综合征相关性的临床研究

目的 探讨阻塞性睡眠呼吸暂停/低通气综合征(OSAHS)儿童血尿酸(UA)水平变化.方法 2008年9月-2010年3月,经多道睡眠监测确诊的138例OSAHS儿童纳入研究组,另有65名副耳及上睑下垂的儿童为正常对照组,另外,按照呼吸暂停低通气指数(AHI)或阻塞性呼吸暂停指数将研究组儿童分为轻度组、中度组、重度组3组,再将研究组和对照组按照体质量指数(BMI)各自再分成超重和肥胖组、非超重和肥胖组,比较各组间晨起空腹血UA水平.再分别进行研究组伴或不伴超重和肥胖儿童血UA水平与AHI、BMI、氧减饱和指数、最低血氧饱和度(LSaO2)及血氧饱和度低于0.92时间所占睡眠总时间百分比之间的相关性分析.结果 (1)研究组与对照组之间(z=-0.443)、研究组OSAHS不同病情(x2=1.241)之间的血UA水平差异无统计学意义(P＞0.05).(2)超重和肥胖儿童血UA水平:无论研究组[273.0(238.3～357.3)]还是对照组[298.0(253.0～336.0)],均高于非超重和肥胖儿童[研究组246.5(215.8～300.0),对照组266.0(224.0～303.3)],差异均有统计学意义(z=-2.084,-2.214,P＜0.05).(3)伴或不伴超重和肥胖的研究组血UA水平与AHI、BMI、氧减饱和指数、LSaO2及血氧饱和度低于0.92时间所占睡眠总时间百分比等指标之间无相关性.结论 与对照组相比,研究组患儿血UA水平无明显升高,两组中超重和肥胖者血UA水平高于非超重和肥胖者,儿童血UA水平与AHI、BMI、氧减饱和指数、LSaO2及血氧饱和度低于0.92时间所占睡眠总时间百分比等指标之间无相关性.伴超重和肥胖的OSAHS儿童及对照组儿童的血UA水平显著高于非超重和肥胖的OSAHS儿童及对照组儿童.

Abstract：

Objective To explore the level of serum uric acid (UA) in children with obstructive sleep apnea/hypopnea syndrome (OSAHS). Method Between Sep. 2008 and Mar. 2010, 138 children with OSAHS were enrolled in study group. Sixty-five children with accessory auricle or ptosis of upper lid were enrolled into the control group. Furthermore, according to apnea/hypopnea index (AHI) or obstructive apnea index ( OAI ) the study group was further divided into three subgroups ( mild, moderate and severe group). At last, the study group and control group were divided into two groups according to the body mass index (BMI), separately. The fasting serum UA level was compared among the different groups. Then the correlation between the serum UA level and AHI, BMI, oxygen desaturation index, least arterial oxygen saturation ( LSaO2 ) and the percentage of total sleep time with arterial oxygen saturation ＜ 0. 92 was also analyzed in OSAHS children with or without overweight and obesity respectively. Result The difference of serum UA level between the study group and control group ( z = - 0. 443 ), and the difference among the three groups (x2 = 1. 241 ) was not significant(P ＞0. 05). The serum UA level in overweight and obese children[study group, 273.0 (238.3 - 357. 3 ); control group, 298.0 ( 253.0 - 336. 0)]was significantly higher than that in children with normal BMI[study group, 246. 5(215.8 -300. 0); control group, 266. 0 (224. 0 - 303.3 )](z = - 2. 084, - 2. 214, P ＜ 0. 05 ). That serum UA level did not correlate with the above index of OSAHS was observed in children with or without overweight and obesity in study group ( P ＞0. 05 ).Conclusion Findings of higher serum UA level were not observed in children with OSAHS. There was no correlation between serum UA level and the above indices of OSAHS. The serum UA level in overweight and obese children was significantly higher than that in children with normal BML.

Correlation between serum uric acid levels and obstructive sleep apnea/hypopnea syndrome in children

Objective To explore the level of serum uric acid (UA) in children with obstructive sleep apnea/hypopnea syndrome (OSAHS). Method Between Sep. 2008 and Mar. 2010, 138 children with OSAHS were enrolled in study group. Sixty-five children with accessory auricle or ptosis of upper lid were enrolled into the control group. Furthermore, according to apnea/hypopnea index (AHI) or obstructive apnea index ( OAI ) the study group was further divided into three subgroups ( mild, moderate and severe group). At last, the study group and control group were divided into two groups according to the body mass index (BMI), separately. The fasting serum UA level was compared among the different groups. Then the correlation between the serum UA level and AHI, BMI, oxygen desaturation index, least arterial oxygen saturation ( LSaO2 ) and the percentage of total sleep time with arterial oxygen saturation ＜ 0. 92 was also analyzed in OSAHS children with or without overweight and obesity respectively. Result The difference of serum UA level between the study group and control group ( z = - 0. 443 ), and the difference among the three groups (x2 = 1. 241 ) was not significant(P ＞0. 05). The serum UA level in overweight and obese children[study group, 273.0 (238.3 - 357. 3 ); control group, 298.0 ( 253.0 - 336. 0)]was significantly higher than that in children with normal BMI[study group, 246. 5(215.8 -300. 0); control group, 266. 0 (224. 0 - 303.3 )](z = - 2. 084, - 2. 214, P ＜ 0. 05 ). That serum UA level did not correlate with the above index of OSAHS was observed in children with or without overweight and obesity in study group ( P ＞0. 05 ).Conclusion Findings of higher serum UA level were not observed in children with OSAHS. There was no correlation between serum UA level and the above indices of OSAHS. The serum UA level in overweight and obese children was significantly higher than that in children with normal BML.