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| 盐酸伊立替康脂质体制备的影响因素考察 | |
| 引用本文： | 杨建坤,刘宏伟,张俭俭,谢瑞娟,刘慧光,曹德英. 盐酸伊立替康脂质体制备的影响因素考察[J]. 中国新药杂志, 2007, 16(23): 1962-1964 |
| 作者姓名： | 杨建坤 刘宏伟 张俭俭 谢瑞娟 刘慧光 曹德英 |
| 作者单位： | 1. 河北大学附属医院药剂科,保定,071000 2. 中国人民武装警察部队学院医院药剂科,廊坊,065000 3. 河北医科大学药学院,石家庄,050017 |
| 摘 要： | 目的:对盐酸伊立替康的脂质体制备方法进行考察。方法:在预实验的基础上初步确定盐酸伊立替康脂质体的制备方法和处方,然后通过单因素考察初步确定影响脂质体制备的因素。结果:硫酸铵梯度法制备的盐酸伊立替康脂质体包封率较高(75.40%),且能保持药物活性。结论:采用硫酸铵梯度法制备脂质体给药系统,制备工艺简单,重现性好,质量稳定,是一种很有前途的靶向给药系统。 |
| 关 键 词： | 盐酸伊立替康 脂质体 硫酸铵梯度法 包封率 |
| 文章编号： | 1003-3734（2007）23-1962-04 |
| 收稿时间： | 2007-08-14 |
| 修稿时间： | 2007-08-14 |
Study on preparation of irinotecan hydrochloride liposomes and its influence factors |
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| YANG Jian-kun,LIU Hong-wei,ZHANG Jian-jian,XIE Rui-juan,LIU Hui-guang,CAO De-ying. Study on preparation of irinotecan hydrochloride liposomes and its influence factors[J]. Chinese Journal of New Drugs, 2007, 16(23): 1962-1964 | |
| Authors: | YANG Jian-kun LIU Hong-wei ZHANG Jian-jian XIE Rui-juan LIU Hui-guang CAO De-ying |
| Abstract: | Objective:To optimize the preparation method of irinotecan hydrochloride(CPT-11) liposomes by the entrapment efficiencies.Methods:On the basis of preliminary experiments,CPT-11 liposome preparation methods were evaluated and then the single factor prescription were used for the identification of factors affecting CPT-11 liposome preparation.Results:The ammonium sulfate gradient method was used to prepare CPT-11 and get higher entrapment efficiency(75.40%).Conclusion:Ammonium sulfate gradient method for CPT-11 liposome preparation is simple and efficient. |
| Keywords: | irinotecan hydrochloride(CPT-11) liposome ammonium sulfate gradient method entrapment efficiency |
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