虎杖水提和乙醇提取物抗抑郁作用的比较

目的:考查虎杖水提物(HZ-W)和虎杖75％乙醇提取物(醇提物,HZ-E)的抗抑郁作用.方法:雄性昆明种小鼠随机分为模型组、盐酸氟西汀(FH,10 mg ·kg-1)、HZ-W(1.5,3 g·kg-1)和HZ-E(1.5,3 g·kg-1)组,连续灌胃(ig)给药7d,1次/d,末次给药后1h,进行悬尾实验(TST)、强迫游泳实验(FST)和开场实验(OFT)测试.结果:模型组小鼠TST和FST不动时间分别为(95.83±17.18),(126.00±20.79)s,HZ-W低剂量和高剂量、HZ-E高剂量以及FH均显著缩短了不动时间(P＜0.05),而HZ-E低剂量对此无显著影响.OFT中,模型组小鼠3 min内穿格次数为(88.44±19.22)次,各给药组与之相比均无显著差异.结论:首次证实HZ-W和HZ-E均具有抗抑郁活性,且以HZ-W作用更强.

Antidepressant Effect of Extracts from Rhizome of Polygonum cuspidati

Objective: To investigate the antidepressant effect of extracts of the water (HZ-W) and 75% ethanol (HZ-E) from rhizome of Polygonum cuspidatum Sieb. et Zucc. Method: Mice were treated with HZ-W(1.5, 3 g·kg^-1), HZ-E(1.5, 3 g·kg^-1), and fluoxetine hydrochloride (FH, 10 mg·kg^-1) everyday for seven consecutive days by intragastric administration (ig). The mouse forced swim test (FST), tail suspension test (TST) and open field test (OFT), were used to observe antidepressant activities of HZ-W and HZ-E, respectively, at 1 h after the last administration. Result: The immobility time of TST and FST in model mice was (95.83±17.18), (126.00±20.79) s respectively and there was significant decrease among HZ-W(1.5, 3 g·kg^-1), HZ-E(3 g·kg^-1), FH(10 mg·kg^-1) groups compared with model group. The numbers of crossing squares in 3 min in model mice during OFT were (88.44±19.22), and there was no significant difference among HZ-W, HZ-E, FH groups compared with model group. Conclusion: The present study firstly indicates that HZ-W and HZ-E exerts antidepressant activity and the former is more potent than the latter at the same dose.