| 正交设计喷雾干燥工艺制备麦冬皂苷肠溶微球 |
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| 引用本文： | 沈岚,冯怡,徐德生,林晓. 正交设计喷雾干燥工艺制备麦冬皂苷肠溶微球[J]. 中国中药杂志, 2006, 31(23): 1947-1950 |
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| 作者姓名： | 沈岚 冯怡 徐德生 林晓 |
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| 作者单位： | 1. 上海中医药大学,药剂教研室,上海,201203
2. 上海中医药大学,附属曙光医院,上海,200021 |
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| 摘 要： | 目的：探索喷雾干燥工艺制备麦冬皂苷肠溶微球的最优工艺参数。方法：以外观形态、包封率、收率等为指标,采用正交设计对喷雾干燥工艺参数进行优选。结果：最优工艺参数：进风温度90 ℃,加料速度10 mL·min-1,雾化器转速50 r·min-1。结论：麦冬皂苷肠溶微球质量符合预期要求；影响微球成型的主要因素为进风温度；喷雾干燥技术制备中药微球有利于工业化生产。
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| 关 键 词： | 喷雾干燥 正交设计 麦冬皂苷肠溶微球 |
| 文章编号： | 1001-5302（2006）23-1947-04 |
| 收稿时间： | 2005-05-15 |
| 修稿时间： | 2005-05-15 |
Studies on using spray drying technique in preparing Ophiopogon Japonicus saponin enteric microsphere by orthogonal experimental design |
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| SHEN Lan ; FENG Yi ; XU De-sheng ; LIN Xiao. Studies on using spray drying technique in preparing Ophiopogon Japonicus saponin enteric microsphere by orthogonal experimental design[J]. China Journal of Chinese Materia Medica, 2006, 31(23): 1947-1950 |
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| Authors: | SHEN Lan FENG Yi XU De-sheng LIN Xiao |
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| Affiliation: | Shanghai University of traditional Chinese medicine, Shanghai 201203, China. |
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| Abstract: | OBJECTIVE: To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique. METHOD: The best technique parameters were investigated by orthogonal experimental design and by the target, such as surface appearances, encapsulated efficiency, etc. RESULT: The best technique parameters included the inlet temperature (90 degrees C ), the feeding speed (10 mL x min(- 1)), and the rotate speed of atomizer (50 r x min(-1)). CONCLUSION: Ophiopogon japonicus saponin enteric microsphere accorded with the expecting demand. The main influencing factor was inlet temperature . It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere. |
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| Keywords: | spray drying technique orthogonal experimental design Ophiopogon Japonicus saponin enteric microsphere |
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