慢性CHF患者BNP与AT-Ⅱ及ALD水平的探讨

目的：探讨慢性充血性心力衰竭患者血中脑利钠肽（BNP）与血管紧张素-Ⅱ（AT-Ⅱ）及醛固酮（ALD）的水平,并进行相关性分析,以提示其在充血性心力衰竭（CHF）发展中的临床意义和价值。方法：使用美国博适公司生产的Triage Meter Plus型免疫荧光定量心衰快速检测仪,检测全血BNP水平。采用放射免疫分析（RIA）受试者血浆AT-Ⅱ、ALD含量。结果：CHF组BNP、AT-Ⅱ、ALD均显著高于对照组,且BNP与AT-Ⅱ、ALD水平呈正相关（P〈0.05）,治疗后血中水平均下降与治疗前差异有显著性（P〈0.01）。结论：同步监测BNP、AT-Ⅱ、ALD有助于早期发现CHF,判断病情及预后。

Study on Plasma Levels of Brain Natriuretic Peptide,Angiotensin and Aldosterone in Patients with Congestive Heart Failure

Objective To investigate the relationship between brain natriuretic peptide（BNP）,angiotensin（AT-Ⅱ）,and aldosterone（ALD） levels in patients with congestive heart failure（CHF）.Methods Plasma levels of BNP（with CLIA） and Angiotensin Ⅱ（AT-Ⅱ）,aldosterone（ALD）（with RIA） were measured in 98 patients with CHF,76 cardiac patients without heart faclure,and 86 controls.Results The plasma levels of BNP,AT-Ⅱ and ALD in patients（with RIA） CHF were significantly higher than those in the controls.The levels of BNP,AT-Ⅱ and ALD,CHF patients after therapy were markedly dropped and were significantly lower than those patients before therapy（P〈0.01）.BNP levels were positively correlated with AT-Ⅱ and ALD in levels CHF（P〈0.05）.Conclusion The over activity of RAA systems may be one of the mechanisms of heart failure.Dynamic observation of changes of BNP,AT-Ⅱ and ALD may be very useful in assessment of severity and prognosis of patients with CHF.