Genomic mismatch scanning in pedigrees

The new method of genomic mismatch scanning allows the high-resolutionmapping of identity by descent on the chromosomes of two relatedindividuals. Modelling recombinant events as a continuous Markovprocess, the authors design experiments and statistical testsfor the use of this technique on sets of affected individualsin pedigrees in order to determine candidate regions for genescontributing to the disease.