补碘对缺碘地区人群垂体—甲状腺功能的影响

目的；观察补碘对缺碘人群垂体－甲状腺功能的影响。方法：应用免疫放射分析和放射免疫分析测定缺碘地区人群口服碘油前后的垂体－甲状腺激素变化。结果：补碘早期引起缺碘机体甲状腺激素水平异常变化，导致甲状腺功能紊乱；中期使缺碘造成的甲状腺功能高代偿状态基本趋于正常；后期机体因碘营养水平下降，使甲状腺功能又呈代学状态。结论：补碘虽可显著改善缺碘造成的甲状腺功能高代偿状态，但早期会造成部分机体垂体－甲状腺功能紊乱，发生一过性亚临床性甲状腺疾病。

Effects of Supplying Iodine on Pituitary and Thyroid Function in Inhabitants with Iodine Deficiency

Objective To study the effects of supplying iodine on pituitary and thyroid function in inhabitants with iodine defeiciency.Methods The changes of serum pituitary and thyroid hormones in inhabitants with iodine deficiency were continuously tested by RIA or IRMA before and after administrating oral iodized capsule.Results Supplying iodine at early period could cause the abnormal changes of thyroid hormones and result in thyroid disorders.At mid-period the status of high compensatory of thyroid function caused by iodine deficiency was nearly normal.But it was in the state of compensatory again for lacking of iodine.Conclusion Although supplying iodine for the bodies with iodine deficiency could improve the status of high compensatory caused by iodine deficiency,it might result in the disorders of pituitary and sub-clinical thyroid disease of short duration.