| 肠集聚性大肠杆菌研究进展 |
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| 引用本文： | 刘学通,熊衍文,徐建国. 肠集聚性大肠杆菌研究进展[J]. 疾病监测, 2012, 27(10): 828-833. DOI: 10.3784/j.issn.1003-9961.2012.10.021 |
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| 作者姓名： | 刘学通 熊衍文 徐建国 |
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| 作者单位： | 中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,北京102206 |
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| 基金项目： | “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（No.2011ZX10004-001） |
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| 摘 要： | 肠集聚性大肠杆菌(enteroaggregative Escherichia coli, EAEC)是一类新发现的致泻性大肠杆菌。该菌目前已在世界各发达、发展中国家出现散发或暴发流行。我国虽尚未报道EAEC的散发或暴发,但仍需给予足够重视。EAEC的致病机制相对复杂,且不同菌株基因组异质性(多态性)较大,其感染后的临床表现不一,诊断治疗更要综合考虑多方面的因素。本文将从EAEC的流行病学特征、致病机制、临床表现、诊断和治疗等方面,对这一新发的肠道病原体做一综述。
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| 关 键 词： | 肠集聚性大肠杆菌 流行病学 毒力因子 致病机制 |
| 收稿时间： | 2012-06-06 |
Progress in research of enteroaggregative Escherichia coli |
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| LIU Xue-tong,XIONG Yan-wen,XU Jian-guo. Progress in research of enteroaggregative Escherichia coli[J]. Disease Surveillance, 2012, 27(10): 828-833. DOI: 10.3784/j.issn.1003-9961.2012.10.021 |
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| Authors: | LIU Xue-tong XIONG Yan-wen XU Jian-guo |
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| Affiliation: | . National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China |
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| Abstract: | Enteroaggregative Escherichia coli （EAEC） is an emerging diarrheal pathogen. EAEC has caused sporadic infections and outbreaks in both developing and developed countries. We should pay more attention to this pathogen though no EAEC infection has been reported in our country. The pathogenesis of EAEC is complicated, and the strains are highly heterogeneous （polymorphic）. The clinical manifestations are various and many factors influence the diagnosis and treatment of EAEC infection. This paper will summarize the pathogenesis of EAEC and the epidemiological characteristics, clinical manifestation and diagnosis/treatment of EAEC infection. |
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| Keywords: | enteroaggregative Escherichia coli epidemiology virulence factor pathogenesis |
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